Banks are the primary intermediaries for the reason that in various countries of the world, they carry out financial intermediation. Through the years, different countries have gone through an unprecedented number of failures in the commercial banks internationally. These failures have prompted the need for a more serious focus on suitable methods of improving the financial performance of national financial systems. Further than the intermediation task, the banks’ financial performance of banks carries a huge implication to expansion of an economy. The fall down in banks’ financial performance has been worrying. The study examined the consequence of prudential regulations on financial performance of Kenyan banks. The explicit goal was to examine the effect of capital adequacy, liquidity and credit risk regulation on financial performance of Kenyan banks. Finally, the study examined the moderating effect bank size on the interlink between prudential regulations and financial performance of banks. Stakeholder Theory, Liquidity Preference and Market Power theory was of guidance. Causal design of research was utilized in the study. The population target was 42 banks operational from 2013 up to 2018. Census was the approach of gathering data. The data to be collected was secondary in nature. The analysis involved the application of both descriptive and panel regression analysis. In analyzing, STATA software was used. The findings revealed regulation of capital adequacy had a statistically significant influence on the financial performance of banks at p value (p=0.000